[关键词]
[摘要]
目的 研究乌拉尔甘草Glycyrrhiza uralensis根的化学成分。方法 利用硅胶、聚酰胺、MCI、ODS、Sephadex LH-20柱色谱,RP-HPLC等技术对乌拉尔甘草70%乙醇提取物的醋酸乙酯萃取部位进行分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定。结果 分离得到14个化合物,分别鉴定为3,7-二甲基甘草黄酮醇(1)、甘草宁I(2)、甘草香豆酮(3)、8-甲雷杜辛(4)、2′-hydroxyisolupalbigenin(5)、异驴食草酚(6)、去氢粗毛甘草素D(7)、glycyrin(8)、甘草酚(9)、刺甘草查耳酮(10)、甘草查耳酮B(11)、isoangustoneA(12)、甘草宁G(13)、5,7,4′-三羟基-6,8-二异戊烯基异黄酮(14)。结论 化合物1为新化合物,化合物2~7首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the roots of Glycyrrhiza uralensis.Methods The chemical constituents in ethyl acetate fraction of 70% ethanol extract from the roots of G.uralensis were isolated and purified by chromatography on silica gel,polyamide,MCI,ODS,Sephadex LH-20 columns,and RP-HPLC.The structures were identified on the basis of physicochemical properties and spectral data analyses.Results Fourteen compounds were isolated and identified as 3,7-dimethyl licoflavonol (1),gancaonin I (2),licocoumarone (3),8-methylretusin (4),2′-hydroxyisolupalbigenin (5),isovestitol (6),dehydroglyasperin D (7),glycyrin (8),glycyrol (9),echinatin (10),licochalcone B (11),isoangustone A (12),gancaonin G (13),and 5,7,4′-trihydroxy-6,8-diisoprenylisoflavone (14).Conclusion Compound 1 is a new compound,and compounds 2-7 are isolated from this plant for the first time.
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[基金项目]
国家自然科学基金资助项目(81173644)