[关键词]
[摘要]
目的 研究炮制辅料羊脂油对淫羊藿炮制品提取物中主要活性成分宝藿苷I在大鼠体内药动学特征的影响。方法 大鼠分别ig给予相同剂量(15 g/kg)的淫羊藿生品提取液、加热品提取液、羊脂油炙品提取液,HPLC-ESI-MS法测定大鼠宝藿苷I血药浓度,经DAS 2.0程序处理数据,比较宝藿苷I药动学参数。结果 3种淫羊藿炮制品提取物在血液中的达峰浓度(Cmax)、药时曲线下面积(AUC)等药动学参数大小为油炙品>加热品>生品,均具有统计学差异。结论 羊脂油能促进淫羊藿提取物中宝藿苷I的口服吸收,提高其生物利用度。
[Key word]
[Abstract]
Objective To research the influence of suet oil on in vivo pharmacokinetic characteristics of icariside I in extract from processed Epimedii Herba in rats. Methods The rats were ig administrated with the extract solutions of raw products, heating products, and processed products (15 g/kg ), respectively. The plasma drug concentration of icariside I was analyzed by HPLC-ESI-MS. The data were processed by program DAS 2.0 and the pharmacokinetic parameters of icariside I were compared. Results The differences of Cmax and AUC among three products were statistically significant (processed products > heating products > raw products). Conclusion Suet oil could promote the oral absorption of icariside I in extract from processed Epimedium Herba and increase the bioavailability.
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[基金项目]
国家自然科学基金资助项目(30572372,30973944);江苏省六大人才高峰资助项目(2009);江苏省中医药科学技术项目(LZ09067)