[关键词]
[摘要]
目的优选青礞石的炮制工艺参数,为控制青礞石炮制品质量及其安全性奠定基础。方法通过多项指标评价,首先筛选出是否需用火硝进行炮制;再采用L9(34)正交优选法,以青礞石炮制品的外观颜色、疏松度、溶出率等筛选炮制工艺参数。结果最佳炮制工艺为在700℃、青礞石与火硝质量配比1∶0.4、摊层厚度2 cm条件下煅制2 h。结论该工艺条件稳定、合理、可行,为矿物类中药的炮制工艺提供了研究思路与方法。
[Key word]
[Abstract]
Objective To optimize the processing parameters and lay the fundation for the quality control and safety of Chloriti Lapis. Methods Evaluated by a number of indexes, whether potassium nitrate was needed in processing was decided. And then using surface color, bulk density, and water dissolution rate to optimize the optimized processing parameters of Chloriti Lapis by L9(34) orthogonal test. Results The optimum processing technology was the weight ratio of Chloriti Lapis-nitre at 1:0.4, thickness of layer-share with 2 cm, at temperature 700 0C, and processed for 2 h. Conclusion The processing technology is stable, reasonable, and feasible, and provides the research thinking and method for processing technology of mineral Chinese medicine.
[中图分类号]
[基金项目]
国家“十一五”科技支撑计划项目(2006BAI55B02);江苏省普通高校研究生创新计划项目(CX09B-282Z);江苏省名老中医药专家师承项目(2009);南京中医药大学中药学一级学科开放课题资助项目(2011ZYX1-002)