[关键词]
[摘要]
目的研究毛茛科植物黄连Coptis chinensis根茎的化学成分。方法利用硅胶柱色谱、凝胶柱色谱、高效液相色谱等技术对黄连95%乙醇提取物进行分离,根据理化性质与光谱数据鉴定化合物的结构。目的从黄连95%乙醇提取物的氯仿萃取部分分离得到10个化合物,分别鉴定为N-顺式阿魏酰基酪胺(1)、唐松草林碱(2)、(S)-2-吡咯烷酸-5-甲酸乙酯(3)、5-羟基吡啶-2-甲酸甲酯(4)、3-吲哚甲醛(5)、环-(苯丙-亮)二肽(6)、环-(苯丙-缬)二肽(7)、开环异落叶松脂醇(8)、n-butyl 3-O-feruloylquinate(9)、methyl 3-O-feruloylquinate(10)。结论化合物1~8为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents in the rhizomes of Coptis chinensisMethods The compounds were separated and purified by column chromatography and their structures were established by spectroscopic methodsResults Ten compounds were isolated from the chloroform extract in the rhizomes of C. chinensis and their structures were identified as N-cis-ferulyltyramine (1), thalifoline (2), ethyl 2-pyrrolidinone-5(S)-carboxylate (3), methyl-5-hydroxy-2-pyridinecarboxylate (4), 1H-indole-3-carboxaldehyde (5), cyclO-(Phe-Leu) (6), cyclO-(Phe-Val) (7), secoisolariciresinol (8), n-butyl 3-O-feruloylquinate (9), and methyl 3-O-feruloylquinate (10)Conclusion Compounds 1-8 are isolated from the plants in this genus for the first time.
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[基金项目]
国家自然科学基金资助项目(30873368)