[关键词]
[摘要]
目的 研究产自河南的狭苞橐吾Ligularia intermedia的化学成分。方法 应用硅胶色谱技术及重结晶等方法分离化合物,通过现代波谱技术鉴定化合物的化学结构。结果 从狭苞橐吾乙醇提取物中分离鉴定了12个化合物,分别鉴定为6β-羟基-艾里莫芬-7(11)-烯-12, 8α-内酯(1)、6β, 8α-二羟基-艾里莫芬-7(11)-烯-12, 8α-内酯(2)、6β, 8α-二羟基-艾里莫芬-7(11)-烯-12, 8β-内酯(3)、eremoligularin(4)、8β-羟基-艾里莫芬-7(11)-烯-12, 8α-内酯(5)、10β-羟基-艾里莫芬-7(11)-烯-12, 8α-内酯(6)、艾里莫芬-1(10)-7(11)-8(9)-三烯-12, 8-内酯(7)、咖啡酸(8)、棕榈酸(9)、齐墩果酸(10)、β-谷甾醇(11)、β-胡萝卜苷(12)。结论 化合物1~5、7~9为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Ligularia intermedia from Henan Province. Methods Compounds were isolated and purified by silica gel chromatography and recrystallization, and their structures were identified by spectral analysis. Results Twelve compounds from L. intermedia were identified as 6β-hydroxy-eremophil-7(11)-en-12, 8α-olide (1), 6β, 8β- dihydroxy-eremophil-7(11)-en-12, 8α-olide (2), 6β, 8α-dihydroxy-eremophil-7(11)-en-12, 8β-olide (3), eremoligularin (4), 8β- hydroxyeremophil-7(11)-en-12, 8α-olide (5), 10β-hydroxy-eremophil-7(11)-en-12, 8α-olide (6), eremophila-1(10), 7(11), 8(9)-triene- 12, 8-lactone (7), caffeic acid (8), palmitic acid (9), oleanolic acid (10), β-sitosterol (11), and β-daucosterol (12). Conclusion Compounds 1—5 and 7—9 are obtained from this plant for the first time.
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[基金项目]
国家自然科学基金资助项目(81072552);河南省科技创新杰出青年基金资助项目(104100510016)