[关键词]
[摘要]
目的研究布渣叶Microcos paniculata的化学成分。方法采用硅胶、Sephadex LH-20、大孔树脂等柱色谱及制备液相色谱等方法进行分离纯化,根据化合物的理化性质、波谱数据等鉴定结构。结果从布渣叶的醋酸乙酯和正丁醇萃取部位分离并鉴定了12个化合物,分别为异鼠李素(1)、表儿茶素(2)、黑麦草内酯(3)、去氢吐叶醇(4)、香草酸(5)、丁香酸(6)、咖啡酸甲酯(7)、对羟基苯甲酸(8)、对香豆酸(9)、木栓醇(10)、豆甾醇(11)、β-谷甾醇(12)。结论化合物3~7、9~12均为首次从该属植物中分离得到,其中化合物3和4为首次从该属植物中分离得到的单萜类化合物。
[Key word]
[Abstract]
Objective To study the chemical constituents of Microctis Folium (the leaves of Microcos paniculata). Methods The chemical constituents were isolated and purified by column chromatography on silica gel, Sephadex LH-20, macroporous resin, and preparative HPLC, etc. The structures of compounds were elucidated by spectral analysis, comparing physicochemical properties, and TLC with authentic samples. Results Twelve compounds were isolated from the EtOAc and n-butanol fractions of Microctis Folium, and identified as isorhamnetin (1), epicatechin(2), loliolide (3), (+)-dehydrovomifoliol(4), vanillic acid (5), syringic acid (6), methyl caffeate (7), p-hydroxybenzoic acid (8), p-coumaric acid (9), friedelinol (10), stigmasterol (11), and β-sitosterol (12). Conclusion Compounds 3—7 and 9—12 are isolated from the plants in Microctis L. for the first time. Compounds 3 and 4 are firstly reported monoterpenes in this genus.
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[基金项目]
“十一五”国家重大新药创制专项滚动课题:中药质量标准研究和信息化体系建设平台(2009ZX09308-004)