纳米混悬给药系统为改善难溶性中药成分的溶解度和生物利用度提供了一条新的途径。研究具有再分散性能的固体化纳米混悬给药系统，是实现纳米混悬系统稳定化的理想选择，然而，固体化再分散后是否仍呈纳米状态，能否保持良好的再分散性，仍然是亟待解决的关键科学问题。主要综述了中药纳米混悬系统固体化的研究现状，并分析了纳米混悬系统固体化及其再分散稳定性的研究策略，以期“抛砖引玉”，进一步促进中药纳米混悬给药系统制剂理论的完善与发展。

Nanosuspensions (NS) drug delivery system is used as a novel approcah to improve the solubility and bioavailability of poorly soluble ingredients in Chinese materia medica (CMM). Studying on solid redispersibility nanosuspension drug delivery system is the main choice for stabilization of nanosuspension systems. However, whether solid is still in nano state after redispersing or can keep good redispersibility is an urgent scientific point. This paper reviews the research status of nanosuspensions system solidification and analyzes the research strategy of nanosuspensions system solidification and redispersion stability in order to “initiate” further investigations and studies to promote and develop the theory of CMM nanosuspension drug delivery system.

国家自然科学基金资助项目(81102821)