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[摘要]
目的 对绣球防风Leucas ciliata的化学成分进行研究。方法 利用正相硅胶、RP-18柱色谱、葡聚糖凝胶Sephadex LH-20等方法进行分离纯化,根据波谱数据鉴定化合物的结构。结果 从绣球防风乙醇提取物中分离得到12个化合物,通过光谱数据分析,分别鉴定为苜蓿素(1)、crisilineol(2)、胡萝卜苷(3)、stigmast-5-ene-11-ol-3-O-β-glucoside(4)、5, 7-dimethoxy-2-methyl-4-chromanone(5)、3′, 5′, 5, 7-tetramethoxy-4′-O-β-glucoside flavone(6)、5-hydroxy-3′, 4′-dimethoxy-7-O- β-glucoside flavone(7)、acteoside(8)、3, 4-dihydroxy-β-phenylethoxy-O-α-L-arabinopyranosyl-(1′′′′→2″)-α-L-rhamnopyranosyl- (1′′′→3″)-4″-O-caffeoyl-β-D-glucopyranoside(9)、3-hydroxy-4-methoxy-β-phenylethoxy-O-α-L-arabino- pyranosyl-(1′′′′→6″)-α-L- rhamnopyranosyl-(1′″→3″)-4″-O-caffeoyl-β-D-glucopyranoside(10)、leucasin A(11A)和leucasin B(11B)。结论 化合物11A和11B为一对差向异构体,并且为新化合物,其余10个化合物均为首次从该属植物中分离得到。
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[Abstract]
Objective To study the chemical constituents from Leucas ciliata. Methods Silica gel, RP-18, and Sephadex LH-20 column chromatography techniques were used for separation and purification of the compounds and extensive spectral analysis spectrum were employed for structural elucidation. Results Twelve compounds were isolated from ethanol extract of L. ciliata and identified as tricin (1), crisilineol (2), sitosterol-3-O-glucoside (3), stigmast-5-ene-11-ol-3-O-β-glucoside (4), 5, 7-dimethoxy-2- methyl-4-chromanone (5), 3′, 5′, 5, 7-tetramethoxy-4′-O-β-glucoside flavone (6), 5-hydroxy-3′, 4′-dimethoxy-7-O-β-glucoside flavone (7), acteoside (8), 3, 4-dihydroxy-β-phenylethoxy-O-α-L-arabinopyranosyl-(1′′′′→2″)-α-L-rhamnopyranosyl-(1′′′→3″)-4″-O-caffeoyl- β-D-glucopyranoside (9), 3-hydroxy-4-methoxy-β-phenylethoxy-O-α-L-arabinopyranosyl-(1′′′′→6″)-α-L-rhamnopyranosyl-(1′″→3″)- 4″-O-caffeoyl-β-D-glucopyranoside (10), leucasin A (11A), and leucasin B (11B). Conclusion Compounds 11A and 11B are epimers and new compounds, and the other ten compounds are obtained from the plants of Leucas R. Br. for the first time.
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[基金项目]
西南林业大学园林学院园林植物与观赏园艺重点实验室资助项目