[关键词]
[摘要]
目的: 制备乙酰氧基胡椒酚乙酸酯亚微乳剂并考察其性质。方法: 采用高压微射法制备乙酰氧基胡椒酚乙酸酯亚微乳, 优化处方和制备工艺,考察其粒径、电位、载药量和稳定性。结果: 制备的乙酰氧基胡椒酚乙酸酯亚微乳粒径和Zeta电位分别为(175.03±4.28)nm和(?30.80±0.44)mV, 载药量为877.3μg/mL, 在低温避光条件下保存稳定性良好。结论: 制备的乙酰氧基胡椒酚乙酸酯亚微乳粒径小、含药量高, 稳定性良好, 为乙酰氧基胡椒酚乙酸酯的制剂研究提供参考。
[Key word]
[Abstract]
Objective: To investigate the preparation of 1′-acetoxychavicol acetate (ACA) submicron emulsion and its properties. Methods: ACA submicron emulsion was prepared using high pressure homogenization technique. The formulation and preparation technique were optimized, the particle size, Zeta potential, content, and stability were tested. Results: The mean diameter and Zeta potential of ACA submicron emulsion were (175.03 ± 4.28) nm and (?30.80 ± 0.44) mV, respectively. The loading drug amount is about 877.3 μg/mL with a good stability when stored in low-temperature and away from light. Conclusion: The prepared ACA submicron emulsion has a small size particals, high content, and good stability. This method can provide some basis and study on preparation of ACA.
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[基金项目]
河南省重点科技攻关计划项目(112102310022);河南省预研专项基金项目(10yy0036)