伴随着药物代谢研究新技术、新方法的发展和代谢组学的出现,建立基于药物体内代谢过程的中药配伍禁忌研究思路和方法, 研究和评价配伍禁忌的反药组合药物在体内的吸收、分布、代谢、排泄过程, 揭示其致毒增毒、减效降效的可能途径、内在机制及其影响因素等科学实质, 为中药科学配伍及临床合理用药提供指导,为中药配伍禁忌研究提供借鉴和示范。

With the development of new technology and new method as well as the appearance of metabolomics, the incompatibility of Chinese materia medica (CMM) could be studied based on the created thoughts and established methods of drug metabolic and pharmacokinetic process in vivo. The absorption, distribution, metabolism, and excretion (ADME) process of incompatible CMM should be studied and evaluated, so as to reveal the possible pathway, mechanism, and impact factor of its toxic production, potentiation, and efficacy reduction of the compatibility. This study will provide the instruction for scientific compatibility, the clinical reasonable application of CMM, and the reference and demonstration for CMM incompatibility study.

国家重点基础研究发展计划(“973”计划)项目(2011CB505300-3)