[关键词]
[摘要]
目的 研究延龄草Trillium tschonoskii根及根茎中的化学成分。方法 采用硅胶、聚酰胺、反相硅胶C18和Sephadex LH-20柱色谱对延龄草70%乙醇提取物进行了分离纯化。用质谱、一维及二维核磁等波谱学方法确定了化合物结构。结果 从延龄草醋酸乙酯和正丁醇部位分离鉴定得到8个化合物,分别鉴定为偏诺皂苷元-3-O-α-L-吡喃鼠李糖基-(1→2)-β-D-葡萄糖苷(1)、偏诺皂苷元-3-O-α-L-吡喃鼠李糖基-(1→4)-[α-L-吡喃鼠李糖基-(1→2)]-β-D-葡萄糖苷(2)、偏诺皂苷元-3-O-α-L-吡喃鼠李糖基-(1→4)-α-L-吡喃鼠李糖基-(1→4)-[α-L-吡喃鼠李糖基-(1→2)]-β-D-葡萄糖苷(3)、偏诺皂苷元(4)、薯蓣皂苷元(5)、7, 11-dimethyl-3-methylene-1, 6-dodecadien-10, 11-dihdroxyl-10-O-β-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside(6)、7, 11-dimethyl-3-methylene-1, 6-dodecadien-10, 11-dihdroxyl-10-O-β-D-glucopyranoside(7)、紫云英苷(8)。结论 所有化合物均为首次从该种植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents in the roots and rhizomes of Trillium tschonoskii. Methods The roots and rhizomes of T. tschonoskii were extracted with 70% ethanol and separated by polyamide, silica gel, RP-C18, and Sephadex LH-20 column chromatography. Chemical structures were identified by MS, 1D and 2D NMR spectroscopy. Results Eight compounds were isolated and their structure were identified as pennogenin-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (1), pennogenin-3- O-α-L-rhamno-pyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (2), pennogenin-3-O-α-L-rhamnopyranosyl- (1→4)-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (3), pennogenin (4), prosapogenin (5), 7, 11-dimethyl-3-methylene-1, 6-dodecadien-10, 11-dihdroxyl-10-O-β-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside (6), 7, 11- dimethyl-3-methylene-1, 6-dodecadien-10, 11-dihdroxyl-10-O-β-D-glucopyranoside (7), and astragalin (8). Conclusion All these compounds are isolated from T. tschonoskii for the first time.
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[基金项目]
江西教育厅青年基金资助项目(GJJ10210);“产学研结合培养高素质复合型中药人才模式创新研究与实践”项目(教高函[2007]29号)