[关键词]
[摘要]
目的 研究麻黄属植物草麻黄Ephedra sinica根的黄酮类化学成分。方法 麻黄根用90%乙醇加热回流提取,采用硅胶、Sephadex LH-20、RP-18柱色谱进行分离纯化,通过波谱分析(MS、1H-NMR、13C-NMR)鉴定结构。结果 从草麻黄根的醇提物的醋酸乙酯部分分离得到13个黄酮类化合物,分别鉴定为:麻黄根素A(1)、麻黄宁A(2)、麻黄宁B(3)、麻黄宁D(4)、芹菜素(5)、山柰酚(6)、槲皮素(7)、二氢槲皮素(8)、3′, 4′, 5, 7-四羟基二氢黄酮(9)、儿茶素(10)、表儿茶素(11)、阿夫儿茶精(12)、表阿夫儿茶精(13)。结论 化合物7~13为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the flavonoids from the roots of Ephedra sinica in Ephedra Tourn. ex L. Methods The roots of E. sinica were extracted with 90% ethanol, and isolated and purified by silica gel, Sephadex LH-20, and RP-18 gel column chromatography. All the compounds were identified based on spectral analyses (including MS, 1H-NMR, and 13C-NMR). Results Thirteen flavonoids were isolated from the roots of E. sinica and were characterized as ephedrannin A (1), mahuannin A (2), mahuannin B (3), mahuannin D (4), apigenin (5), kaempferol (6), quercetin (7), dihydroquercetin (8), 3′, 4′, 5, 7-tetrahydroxy flavanone (9), (+)-catechin (10), (?)-epi-catechin (11), afzelechin (12), and (?)-epi-afzelechin (13), respectively. Conclusion Compounds 7—13 are obtained from this plant for the first time.
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[基金项目]
国家自然科学基金青年基金资助项目(40706046)