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[摘要]
目的 研究黄花败酱Patrinia scabiosaefolia的化学成分。方法 采用甲醇提取、溶剂萃取、硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压快速制备及半制备高效液相色谱等方法分离纯化;通过化学方法及核磁共振谱、质谱等光谱数据鉴定化合物结构。结果 分离得到14个化合物,分别鉴定为3-羟基-11-氧代齐墩果酸(1)、3, 11-二氧代齐墩果酸(2)、3-O-木糖-齐墩果酸-28-葡萄糖酯苷(3)、3-氧代-29-羟基齐墩果酸(4)、3β, 12α-二羟基-13β, 28-内酯齐墩果酸(5)、3-鼠李糖-(1→2)-木糖-齐墩果酸-28-葡萄糖酯苷(6)、愈创木-6(7)-烯-4, 10-二醇(7)、3α-乌苏酸(8)、豆甾醇(9)、麦角甾- 6, 22-二烯-3β, 5α, 8α-三醇(10)、齐墩果酸-3-O-β-D-吡喃木糖苷(11)、齐墩果酸-3-O-鼠李糖-(1→2)-木糖苷(12)、3-O-木糖- (1→3)-鼠李糖-(1→2)-阿拉伯糖-齐墩果酸-28-葡萄糖酯苷(13)、齐墩果酸-28-O-葡萄糖-(1→6)-葡萄糖酯苷(14)。结论 化合物1~8均为首次从本属植物中分离得到。
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[Abstract]
Objective To study the chemical constituents of Patrinia scabiosaefolia. Methods The constituents were extracted by methanol and isolated by silica gel chromatography, Sephadex LH-20 gel column chromatography, medium pressure column chromatography, and semi-preparative high performance liquid chromatography. Their structures were elucidated by chemical properties and spectroscopic analysis. Results Fourteen compounds were isolated and their structures were identified to be 3-hydroxy-olean-11-oxo-12-en-28-oic acid (1), 3, 11-dioxoolean-12-en-28-oic acid (2), 3-O-β-D-xylopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (3), 29-hydroxy-3-oxo-olean-12-en-28-oic acid (4), 3β, 12α-dihydroxy-oleanan-13β, 28-olide (5), 3-O-rhamnopanosyl-(1→2)-xylopyanosyl-oleanolic acid-28-O-glucopyanosyl ester (6), guaia-6-en-4, 10-diol (7), 3-epi-ursoloic acid (8), stigmasterol (9), ergost-6, 22-dien-3β, 5α, 8α-triol (10), oleanolic acid 3-O-β-D-xylopyranoside (11), oleanolic acid 3-α-L-rhamnopyanosyl-(1→2)-β-D-xylopyranoside (12), 3-O-β-D-xylopyanosyl-(1→3)-α-L-rahmnopyanosyl-(1→2)-α-L-arabino- pyanosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (13), and oleanolic acid 28-O-β-D-glucopyranosyl-(1→6)-β-D- glucopyranosyl ester (14). Conclusion Compounds 1―8 are obtained from the plants of Patrinia Juss. for the first time.
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