对中药胃滞留给药系统（GRDDS）近年来的研究现状进行总结和概述，分析目前制约中药复方GRDDS发展的核心问题，阐述了体内外相关研究体系缺失对于中药复方GRDDS的影响，着重探讨了体内外评价方法及相关性的评价模型，并提出人工神经网络（ANN）应用于中药复方GRDDS体内外相关性模型的可能途径，通过对其进行讨论，分析了ANN模型在GRDDS中应用的优势、特点以及存在的问题，以期为传统中药的创新研发提供参考。

The recent study on gastric retenting drug delivery system (GRDDS) used in Chinese medicinal formule has been summaried and overviewed in this paper. The key problems about the development of GRDDS have been explored，the influence about absence of the system for in vivo-in vitro correlation (IVIVC) analyzed, especially the evaluation on IVIVC model discussed, and the possible approach that artificial neural networks (ANN) are applied in GRDDS for Chinese medicinal formule has been put forward. The processing technology, evaluation of IVIVC, and the advantage, characteristic, and problems of the application of ANN have been studied in order to provide the reference for innovating research of Chinese medicinal formule.

“十一五”重大新药创制项目“中药新型给药系统技术平台”（2009ZX09310-005）；江西省自然科学基金项目（2010GQY0179）；江西省教育厅科技项目（GJJ11549）；国家中医药管理局中医药行业专项——中成药生产过程再现的关键技术示范研究(200807038)