[关键词]
[摘要]
目的比较注射用苦参素纳米球(KU-PLGA-NS)与注射用苦参素普通粉针剂(KUI)在大鼠体内的药动学特性。方法建立HPLC法检测大鼠血浆中苦参素,采用ANOVA法选择房室模型,将所测得的血药浓度-时间数据,采用DAS程序进行分析,根据F值与AIC选择房室模型求算药动学参数。结果等剂量KU-PLGA-NS和KUI的AUC0-t分别为(785.57±170.92)、(342.43±54.49)mg·L-1.min,Cmax为(18.51±2.47)、(28.48±5.40)mg/L,t1/2Ke为(91.69±1.94)、(11.51±2.47)min。结论 KU-PLGA-NS在大鼠体内的药动学特性与KUI比较AUC和Cmax增加,t1/2延长。
[Key word]
[Abstract]
Objective To compare the in vivo pharmacokinetic properties of Kushenin Injection Nanoparticles(KU-PLGA-NS) with the ordinary Kushenin Injection(KUI) of rats.Methods A method has been developed and validated for the quantification of kushenin in rat plasma.Using ANOVA method to choose the compartment model,The plasma concentration-time data were measured and then analyzed by DAS program on the computer.According to F values,the AIC choice compartment model pharmacokinetic parameters were calculated.Results The main pharmacokinetic parameters of KU-PLGA-NS and KUI were as follows: AUC0-t were(785.57 ± 170.92) and(342.43 ± 54.49) mg.L?1.min,respeticevly;Cmax were(18.51 ± 2.47) and(28.48 ± 5.40) mg/L,respeticevly;t1/2Ke were(91.69 ± 1.94) and(11.51 ± 2.47) min,respeticevly.Conclusion Comparison of in vivo pharmacokinetic characteristics of rats between KU-PLGA-NS and KUI has a significant change with AUC and Cmax increase and t1/2 extension.
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[基金项目]
安徽省自然科学基金项目(070413117);安徽医科大学校级研究项目(2008kj12);国家中医药管理局中医药科研三级实验室“中药药理实验室”项目(TCM-2009-197)
