[关键词]
[摘要]
目的研究芒果Mangifera indica叶的化学成分。方法采用正相硅胶、反相ODS、Sephadex LH-20等柱色谱以及高效液相色谱法进行分离纯化,并通过理化性质与光谱分析方法鉴定化合物的结构。结果从芒果叶70%乙醇提取物中分离了11个化合物,分别鉴定为槲皮素-3-O-β-L-鼠李糖苷(1)、金丝桃苷(2)、槲皮素-3-O-β-葡萄糖苷(3)、7-O-甲基槲皮素-3-O-β-L-鼠李糖苷(4)、鼠李糖-3-O-β-葡萄糖吡喃糖苷(5)、穗花衫双黄酮(6)、芒果苷(7)、鸢尾酚酮-3-C-β-葡萄糖苷(8)、桑橙素-3-C-β-葡萄糖苷(9)、2,4',6-三羟基-4-甲氧基二苯甲酮-2-O-β-葡萄糖苷(10)、鸢尾酚酮-3-C-(6-O-p-羟基苯甲酰基)-β-葡萄糖苷(11)。结论化合物4、10为首次从芒果属植物中分离得到,化合物11的NMR数据为首次报道。
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[Abstract]
Objective To study the chemical constituents of Mangifera indica leaves.Methods Silica gel,ODS,Sephadex LH-20 column chromatography,and HPLC were used to isolate and purify the constituents,and their structures were identified by physicochemical properties and spectral data.Results Eleven compounds were isolated from 70% ethanol extract,and identified as quercetin-3-O-β-L-rhamnopyranoside(1),hyperin(2),quercetin-3-O-β-glucopyranoside(3),7-O-methylquercetin-3-O-β-L-rhamnopyranoside(4),rhamnetin-3-O-β-D-glucopyranoside(5),amentoflavone(6),mangiferin(7),irisflophenone-3-C-β-glucoside(8),maclurin-3-C-β-glucoside(9),2,4',6-trihydroxy-4-methoxybenzophenone-2-O-β-glucoside(10),and irisflophenone-3-C-(6-O-p-hydroxybenzoyl)-O-β-glucoside(11),respectively.Conclusion Compounds 4 and 10 are obtained from the plants of Mangifera L.for the first time,and the NMR data of compound 11 is reported for the first time.
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[基金项目]
教育部科学技术重点研究项目(209002);“重大新药创制”科技重大专项项目——现代中药新药发现和评价技术平台(2009ZX09311-002);科技部国际合作项目(2008DFB30070)