[关键词]
[摘要]
目的 优化β-榄香烯聚氰基丙烯酸正丁酯纳米粒的制备工艺。方法 以聚氰基丙烯酸正丁酯(polybutylcyanoacrylate,PBCA)为载药材料,采用界面缩聚法,以包封率为考察指标,通过单因素试验及正交试验设计优化制备工艺。结果 该工艺条件下制得的纳米粒,形态规整,无黏连,大小较为均匀,平均粒径254 nm,平均包封率90.17%。结论 本实验优化的制备工艺稳定可行。
[Key word]
[Abstract]
Objective Optimizing the formula and preparation of β-elemene-polybutylcyanoacrylate nanoparticles (β-ELE-PBCA- NP). Methods With polybutylcyanoacrylate (PBCA) as the drug-loaded material, β-ELE-PBCA-NP was prepared by interfacial polycondensation. The preparation conditions were optimized by single factor design and the formula was optimized by orthogonal design with entrapment efficiency (EE) as index. EE of β-ELE-PBCA-NP was determinated by RP-HPLC. Results Under the optimal conditions, the prepared NPs were round and regular in shape without adhesions with average particle size of 254 nm and EE of 90.17%. Conclusion The optimized technology in this experiment is stable and feasible.
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[基金项目]
辽宁省教育厅2009年度高等学校科研项目(2009A499);辽宁中医药大学优秀青年药学人才基金