目的 比较骨碎补超微粉和普通粉的粉体学特征及溶出特点，为骨碎补超微粉体的粒径控制与应用提供实验依据。方法 通过考察骨碎补粉体的粒径及分布、吸湿性、粉体的形貌结构等粉体学特征和体外溶出行为，研究骨碎补粉体的粒径对其粉体学特性和体外溶出行为的影响。结果 骨碎补超微粉和普通粉的粉体学特征、体外溶出行为差异显著；除微粉Ⅲ外，骨碎补超微粉中柚皮苷溶出的速度与程度要高于普通粉。结论 适度的微粉化能促进骨碎补有效成分的溶出，超微粉碎技术应用于骨碎补具有可行性。骨碎补超微粉体粒径宜控制在61.4～23.5 μm。

Objective Comparing the powder characteristics and dissolution rate between common powder and micropowder of Drynariae Rhizoma to provide experimental evidence for the micropowder application and the control of paticle size. Methods Particle size and distribution, hygroscopicity, and powder morphology of the powder characteristics and dissolution behavior were used to evaluate the impact of particle size on powder characteristics and dissolution of Drynariae Rhizoma powders. Results There were significant differences between common powder and micropowder in powder characteristics and dissolution rate. In addition to the micropowder Ⅲ, the dissolution rates and the concentrations of naringin in micropowders were higher than those in the common powder of Drynariae Rhizoma. Conclusion An appropriate degree of micronization is helpful for the dissolution of the active components in Drynariae Rhizoma and the application of micronization technology to Drynariae Rhizoma is feasible. The particle diameter (D₉₀) of the micropowders should be controlled in 61.4—23.5 μm.

“863”国家高技术研究发展计划（2009AA043202）；国家中医药管理局公益性行业科研专项（200807054）；江西省对外科技合作项目（2008BB24800）；江西省教育厅青年科学基金项目（GJJ10214）；江西省卫生厅中医药科研计划（2010A101）