目的探讨模糊综合评价法在促透剂促透效果综合评价中的运用。方法以茶碱为模型药物,氮酮为阳性促透剂,研究中药促透剂薄荷醇、樟脑、丁香油、荆芥油、广藿香油对模型药物在离体SD大鼠背部皮肤上的透皮行为的影响,计算渗透系数、稳态流量、滞后时间、增渗倍数,运用模糊综合评价法对促透效果进行综合评价。结果对茶碱的促渗作用,1%丁香油表现为优,1%氮酮表现为良,1%薄荷醇、1%樟脑、1%广藿香、1%荆芥油表现为中。结论模糊综合评价法可客观地评价促透剂的促透效果。

Objective. T o investigate the utilization of fuzzy comprehensive eva.luation method for eva.luating the promoting effect of transdermal enhancer? Methods. T aking theophylline as drug model,Azone as positive transdermal enhancer, the penetrating srates, teady fluxes, lag time, and enhancement ratio were calculated. Menthol camphor, dove oil, Schiz onepeta temuif olia oil, and Pogostemon cablin oil using on the back skin of SD rat were observed on the equipment of percutaneous absorption in vitro. The promotion of transdermal enhancers was evaluated by fuzzy comprehensive evaluation method. Results. As for promoting effect on theophylline, 1% dove oil was the best and 1% Azone ranked behind, 1% men.thol, 1% camphor, 1% P. cablin oil, and 1% S. temuif olia oil were medium. Conclusion Fuzzy assess.ment method could be used to evaluate the promoting effect of transdermal enhancers objectively.

广东省科技计划项目(2007A060305006)