目的优化木犀草素-β-环糊精包合物的制备工艺。方法采用饱和水溶液法包合木犀草素,以包合率、收率和总评"归一值"为评价指标,采用Box-Behnken设计考察β-环糊精-木犀草素投料比例、包合时间、包合温度对制备工艺的影响,对结果进行多元线性和二项式拟合,效应面法选取最佳工艺条件进行预测分析。结果从相关系数上看,各项指标二项式拟合方程均优于多元线性回归方程,根据优化制备工艺制得木犀草素-β-环糊精包合物的平均包合率为75%,收率为66%。结论优化的木犀草素-β-环糊精包合物制备工艺稳定可行,包合率和收率同时都高,可用于生产。

Objective To optimize the formulation of cyanidenon-?- cyclodextrin inclusion compound.Methods. Cyanidenon-?- cyclodextrin inclusion compound was prepared by saturated water solution meth-od. The effects of influence factors, such as ingredient proportion, inclusion time, inclusion temperature on inclusion rate, obtaining rate, and overall desirability were investigated by using Box-Behnken design and response surface method. The data were imitated using mult- i linear equation and second-order polyno-mial equation. Results . The latter was prior to the former considering from multiple correlation coeff- icients. Under the optimal conditions, inclusion rate and yield were 75% and 66%, respectively. Conclu-sion. The optimized preparation technique for cyanidenon-?-cyclodextrin inclusion compound is stable, fea-sible, and has high inclusion rate? It can be used for the production of cyanidenon-?-cyclodextrin inclusion compound.