[关键词]
[摘要]
目的研究茜草科耳草属植物水线草Hedyotis corymbosa的化学成分。方法利用柱色谱、制备薄层色谱和重结晶进行分离纯化,通过波谱技术鉴定化合物的结构。结果分离得到13个化合物,分别鉴定为(+)-lyo-niresinol-3α-O-β-D-glucopyranoside(Ⅰ)、槲皮素(quercetin,Ⅱ)、七叶内酯(esculetin,Ⅲ)、东莨菪内酯(scopoletin,Ⅳ)、耳草酮A(hedyotiscone A,Ⅴ)、对羟基苯甲酸(p-hydroxybenzoic acid,Ⅵ)、原儿茶酸(protocatechuic acid,Ⅶ)、香草酸(vanillic acid,Ⅷ)、丁香酸(syringic acid,Ⅸ)、(+)-催吐萝芙叶醇[(+)-vomifoliol,Ⅹ]、(-)-二氢催吐萝芙叶醇[(-)-dihydrovomifoliol,Ⅺ]、S-(+)-去氢催吐萝芙叶醇[S-(+)-dehydrovomifoliol,ⅩⅡ]和茜素1-甲醚(aliza-rin1-methyl ether,ⅩⅢ)。结论化合物Ⅰ~ⅩⅢ均为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents in the whole plant of Hedyotis corymbosa.Methods The compounds were isolated by column chromatography,pre-TLC,and recrystallization.Their structures were elucidated by spectroscopic methods.Results Thirteen compounds were isolated and identified as(+)-lyoniresinol-3α-O-β-D-glucopyranoside(Ⅰ),quercetin(Ⅱ),esculetin(Ⅲ),scopoletin(Ⅳ),hedyotiscone A(Ⅴ),p-hydroxybenzoic acid(Ⅵ),protocatechuic acid(Ⅶ),vanillic acid(Ⅷ),syringic acid(Ⅸ),(+)-vomifoliol(Ⅹ),(-)-dihydrovomifoliol(Ⅺ),S-(+)-dehydrovomifoliol(ⅩⅡ),and alizarin 1-methyl ether(ⅩⅢ),respectively.Conclusion Compounds Ⅰ—ⅩⅢ are isolated from this plant for the first time.
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[基金项目]
上海-SK研究与发展基金资助项目(2004008-t)