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[摘要]
目的应用挤出滚圆法制备芍药总苷速释微丸,用Eudragit RS 100作为包衣材料,制备芍药总苷缓释微丸。方法采用mini Glatt流化床底喷包衣法制备缓释微丸,对其包衣工艺及处方进行单因素考察,评价微丸的粉体学性质和体外释放行为。结果当聚合物包衣增质量为6%,增塑剂用量为10%时,药物具有明显的缓释作用,体外释放曲线符合Peppas和Higuchi方程。结论制备的芍药总苷缓释微丸具备较理想的缓释效果。
[Key word]
[Abstract]
Objective To prepare totel glucosides in paeony(TGP) pellets by extrusion-spheronization and to optimize the formulation of TGP sustained-release pellets coated with Eudragit RS 100.Methods The TGP sustained-release pellets were prepared by mini Glatt fluidized bed coating method.The factors to influence the drug release behaviors and their properties were evaluated.Results The optimal TGP sustained-release pellet was shown significant sustained-releasing at the loading weight of copolymers of 6% and the plasticizer concentration of 10%.And the curves of cumulative drug release were fit for Peppas and Higuchi equation.Conclusion The pellets showed an obviously sustained-release effect.
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[基金项目]
上海市重点学科建设项目(T0301);上海市科委项目(04DZ19841);高等学校博士学科点专项科研基金资助项目(20060268009)