[关键词]
[摘要]
目的研究大叶千斤拔根的化学成分。方法采用柱色谱及薄层色谱进行分离纯化,根据其理化性质及波谱数据鉴定化学结构。结果分离得到个化合物,其中异黄酮4个,双氢黄酮3个,黄烷醇个,分别是染料木素(Ⅰ)、5,7,3',4'-四羟基异黄酮(Ⅱ)、5,7,4'-三羟基异黄酮-7-O-β-D-吡喃葡萄糖苷(Ⅲ)、5,7,4'-三羟基-8,3'-二异戊烯基双氢黄酮(Ⅳ)、5,7,4'-三羟基-6-异戊烯基异黄酮(Ⅴ)、云南千斤拔素(flemichin D,Ⅵ)、胡枝子黄烷酮A(lespedezaflavanone A,Ⅶ)、赛金莲木儿茶精(ouratea-catechin,Ⅷ)、3,4,5-三甲氧基苯-O-β-D-葡萄糖苷(Ⅸ)、豆甾醇-3-O-β-D-吡喃葡萄糖苷(Ⅹ)、豆甾醇(Ⅺ)。结论化合物Ⅲ~Ⅴ、Ⅶ~Ⅺ为首次从该种植物中得到,化合物Ⅰ~Ⅺ为首次从该植物根中得到,其中以生理活性成分染料木素为代表的异黄酮为该植物根的主要成分。
[Key word]
[Abstract]
Objective To study the chemical constituents in the roots of Flemingia macrophylla Methods To separate and purify compounds by column chromatography and TLC, and to determine their chemical structures by their physical characters and spectral data. Results Eleven compounds were purified from the extraction in the roots of F. macrophylla, among them four are isoflavones, three are flavanones, and one is flavanol. They are genistein (Ⅰ), orobol (Ⅱ), 5, 7, 4'-trihydroxyisoflavone-7-O-β-D-glucopyranoside (Ⅲ), 5, 7, 4'-trihydroxy-8, 3'-diprenylflavanone (Ⅳ), 5, 7, 4'-trihydroxy-6-prenylisoflavone (Ⅴ), flemichin D (Ⅵ), lespedezaflavanone A(Ⅶ), ouratea-catechin (Ⅷ), 3, 4, 5-trimethoxybenzene-O-β-D-glucopyranoside (Ⅸ), stigmasterol-3-O-β-D-glucopyranoside (Ⅹ), and stigmasterol (Ⅺ). Conclusion Compounds Ⅲ-Ⅴ, and Ⅶ-Ⅺ are found from this plant for the first time. All the compounds are found from the roots of this plant for the first time. The active components, genistein and its isoflavone analogs, are main constituents in the roots of F. macrophylla
[中图分类号]
[基金项目]
中国科学院知识创新基地基金资助(0303JX28)