[关键词]
[摘要]
目的 应用挤出滚圆法制备芍药甘草方微丸。方法 在考察提取物的物理性质的基础上,用挤出滚圆造粒机分别制备芍药、甘草微丸;采用单因素试验优化制剂处方及工艺条件;评价了微丸的粉体学性质、收率和体外溶出度。结果 用挤出滚圆法制备的芍药、甘草微丸在30min内体外溶出均达90%以上,且圆整度好,收率高。结论 挤出滚圆法制备芍药甘草方微丸工艺简便易行,制得的微丸质量好,收率高,体外释药迅速。
[Key word]
[Abstract]
Objective To study the formulation and process ofShaoyao Gancao formulationpellet by extrusion-spheronization.Methods Based on the physical characters of active parts,the pellets with Shaoyao (Radix Paeoniae Alba) and Gancao (Radix Glycyrrhizae) were prepared separately by extrusion-spheronization.The formulation and processwere studied by direct comparison.Then their characters were evaluated.Results The active components could release more than 90%in 30 min and thepellets presented aperfect sphericity.Conclusion Shaoyao Gancao formulation pellet could be prepared by extrusion-spheronization machine and the pellets show a perfect sphericity.In vitro dissolution is satisfactory with high quality and yield.
[中图分类号]
[基金项目]
上海市重点学科建设项目(T0301);上海市科委项目(04DZ19841);高等学校博士学科点专项科研基金资助项目(20060268009)