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[摘要]
目的对海南狗牙花中的吲哚类生物碱进行分离鉴定。方法采用硅胶、Sephadex LH-20等柱色谱方法进行分离,NMR等波谱学方法进行结构鉴定。结果从海南狗牙花中分离鉴定了7个吲哚类生物碱,分别为:海南狗牙花素(hainanervatasine,Ⅰ)、海南狗牙花新(hainanervatacine,Ⅱ)、老刺木碱(vobasine,Ⅲ)、冠狗牙花定(coronar-idine,Ⅳ)、3-羟基冠狗牙花定(3-hydroxyl coronaridine,Ⅴ)、3-(2-羰基-丙基)冠狗牙花碱[3-(2-oxopropyl)coronar-idine,Ⅵ]、山辣椒胺(tabernamine,Ⅶ)。结论化合物Ⅰ、Ⅱ为新化合物,分别命名为海南狗牙花素(Ⅰ)、海南狗牙花新(Ⅱ),化合物、为首次从该植物中分离得到。
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[Abstract]
Objective To study indole alkaloids of Ervatamia hainanensis.Methods The compounds were separated and purified by columnchromatography with silica gel and Sephadex LH一20.Thestructures were identified by IR,MS,and NMR.Results Seven alkaloids were identified as:hainanervatasine(I),hainanervatacine(I),vobasine(I),eoronaridine(IV),3-hydroxyl coronaridine(V),3一(2-oxopropyl)coronaridine(VI),and tabernamine(Ⅵ),respectively.Conclusion CompoundsI and 1 are new compounds.Compounds lV andⅥare isolated from this plant for the first time.
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