[关键词]
[摘要]
目的通过大鼠胃溃疡实验比较白芨普通粉(80、200目)和超微粉的药效学区别及白芨经超微粉碎后可降低的用药剂量。方法采用大鼠无水乙醇和醋酸致胃黏膜损伤型胃溃疡模型,测定溃疡面积,计算溃疡抑制率;取溃疡部组织切片,做HE染色,从病理学角度进一步观察病理情况。结果白芨粉可明显降低大鼠的溃疡面积,且超微粉疗效优于普通粉。结论超微粉碎后有助于提高白芨的药效,减少用药剂量,有利于剂型现代化。
[Key word]
[Abstract]
ObjectiveTo compare the pharmacodynamics of common Bletilla striata powder (80 and 200 meshes) with ultrafine powder of B.striataon experimental gastriculcer in rats and to clarify how much the dose of B. striata was decreased after superfine comminution. Methods The models of gastriculcer were set up by anhydrous alcohol and aceticacid to measure the gastriculcer area and countout the inhibitory rate; The tissue slice of gastriculcer cicatrix was got far HE staining. Based on the viewpoint of pathology the morbid state was observed. ResultsB. striata powder could decrease the gastriculcer area significantly, and the groups of ultrafine powder were advantaged to the others. ConclusionA fter superfine comminution, the potency of B. striata can be improved with its dose reducing. It is good for modernization of making dosage forms.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(30672672)