[关键词]
[摘要]
目的 研究苦瓜的化学成分。方法 采用乙醇提取、大孔吸附树脂纯化和硅胶柱色谱分离,通过光谱分析鉴定化合物的结构。结果 从苦瓜中分离并鉴定了2对异构体。经13C-NMR光谱分析,其中一对异构体的化学结构初步确定为19R-5β,19环氧葫芦烷-6,23,25-三烯-3β,19-二醇(Ⅰa)和19S-5β,19环氧葫芦烷-6,23,25-三烯-3β,19-二醇(Ⅰb);另一对异构体的化学结构确定为5β,19环氧葫芦烷-6,23,25-三烯-3-O-吡喃葡萄糖苷(Ⅱa)和5β,19环氧葫芦烷-6,23,25-三烯-3-O-阿洛吡喃糖苷(Ⅱb)。结论 化合物Ⅰa、Ⅰb、Ⅱa、Ⅱb均为首次从苦瓜中分离得到的新化合物。
[Key word]
[Abstract]
Objective To study the chemical constituents in Momordica charantia.Methods The alcohol extract was isolated by macroporous adsorption resin and silica gel,and the compound structures were identified by spectral methods.Results Two couple isomers were isolated,the structure of one couple was identified as 19R-5β,19-epoxycucurbita-6,23,25-trien-3β,19-diol(Ⅰa)and 19S-5β,19-epoxycucurbita-6,23,25-trien-3β,19-diol(Ⅰb);the structure of the other couple was identified as 3-O-glucopyranoside of 5β,19-epoxycucurbita-6,23,25-trien-3-ol(Ⅱa),and 3-O-allopyranoside of 5β,19-epoxycucurbita-6,23,25-trien-3-ol(Ⅱb).Conclusion New compounds Ⅰa,Ⅰb,Ⅱa,and Ⅱb are isolated from M.charantia for the first time.
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[基金项目]
辽宁省自然科学基金资助项目(2001101048);辽宁省中小企业创新基金资助项目(20030213)