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[摘要]
目的研究葛根素及其磷脂复合物中葛根素在B eag le犬体内药动学。方法采用HPLC法测定犬血中葛根素,以同组犬(3只,雄性)交叉口服葛根素及其磷脂复合物,药-时曲线数据经3P 97药动学计算程序处理。结果分别以葛根素及其磷脂复合物给B eag le犬口服(剂量为葛根素52.5 m g/kg),葛根素的药-时过程符合开放型双室一级动力学模型,葛根素口服的AUC、Cm ax、tm ax分别为(10.91±4.83)m g.h/L、(3.00±1.13)m g/L、(1.62±0.30)h,而葛根素磷脂复合物的AUC、Cm ax、tm ax分别为(13.67±2.72)m g.h/L、(1.91±0.51)m g/L、(2.38±1.27)h,统计结果表明AUC之间差异有显著性。结论形成磷脂复合物可提高葛根素在B eag le犬体内的吸收。
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[Abstract]
Objective To study the pharmacokinetics of puerarin and its phospholipid complex in Beagle dogs in vivo.Methods To determine the puerarin concentration in blood by HPLC,carry on the cross-experiments in the same group of dogs,and calculate the data using 3P97 pharmacokinetic program software.Results The concentration-time profiles of puerarin after ig puerarin and its phospholipid complex(equivalent to 52.5 mg/kg of puerarin)were shown to fit two-compartment open model with first-order absorption.Their AUC,Cmax:,and fmaxfor puerarin were(10.91±4.83)mg·h/L,(3.00±1.13)mg/L,and(1.62±0.30)h,while for puerarin in phospholipid complex were(13.67±2.72)mg·h/L,(1.91土0.51)mg/L,and(2.38±1.27)h,respectively.Difference in AUC is significant.Conclusion Phospholipid complex formation can effectively enhance puerarin absorption in Beagle dogs in vivo.
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