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[摘要]
目的研究茯苓P oria cocos的化学成分,从中寻找有重要生物活性及药用前景的天然产物。方法采用正相硅胶,反相RP-18,Sephadex LH-20及M C I等柱色谱分离化合物,运用波谱技术分析确定化学结构。结果从茯苓的提取物中共分离并鉴定了13个化合物,经波谱分析确定分别为:麦角甾-7,22-二烯-3β-醇(Ⅰ)、胡萝卜苷(Ⅱ)、茯苓酸(Ⅲ)、3β-乙酰基-16α-羟基-羊毛甾-7,9(11),24(31)-三烯-21-酸(Ⅳ)、3,β16α-二羟基-羊毛甾-7,9(11),24(31)-三烯-21-酸()、16α-羟基-3-羰基-羊毛甾-7,9(11),24(31)-三烯-21-酸()、3β-羟基-羊毛甾-7,9(11),24-三烯-21-酸()、3β-对羟基苯甲酸去氢土莫里酸()、3β,16α-二羟基-羊毛甾-7,9(11),24-三烯-21-酸()、乙基-β-D-吡喃葡萄糖苷()、L-尿苷()、柠檬酸三甲酯()、(R)-苹果酸二甲酯()。结论化合物和~均为首次从该植物中分离得到。
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[Abstract]
Objective To study the chemical constituents from Poria COCOS aiming at searching for bioactive natural products.Methods All compounds were isolated by repeated Si02,LH-20,MCI,and RP-1 8 column chromatography.Their structures were determined by various spectral methods.Results Thirteen compounds were isolated from P.COCOS and their structures were identified by means of spectroscopic analysis as:ergosta-7,22-diene-3pol(I);daucosterol(Ⅱ);pachymic acid(Ⅲ);38-acetyloxy 16a-hydroxylanosta-7,9(11),24(31)-trien-21oic acid(Ⅳ);38,16a-dihydroxy-lanosta-7,9(11),24(31)-trien-21-oic acid(V);16a-hydroxy-3-OXO-lanosta-7,9(11),24(31)-trien-21-oic acid(Ⅵ);38-hydroxylanota-7,9(11),24-trien-21-oic acid(Va);3p户-hydroxybenzoyl-dehydrotumulosic acid(Ⅶ);38,1 6-dihydroxylanosta-7, 9(1 1), 24-trien-21-oic acid(Ⅸ);ethyl-pD-glucopyranoside (x);L-uridine (Ⅺ);trimethyl citrate(XⅡ) and(R)-dimethyl malate(XI).Conclusion CompoundsⅡand X-Xl are found for the first time in P.COCOS.
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