[关键词]
[摘要]
目的探讨应用超滤膜分离技术纯化夏天无总碱工艺。方法采用不同截留分子的膜组件、操作参数进行正交设计,以与原阿片碱相关的各种指标考察不同膜组件及操作参数对膜分离效果的影响。结果截留相对分子质量为6×103~1.0×104的PS膜具有较好的膜分离效果,选择压力0.08MPa、料液温度40℃、进料体积流量2.8L/min的操作参数工作效率更高。结论利用膜分离工艺制备的夏天无注射液澄清、色泽好,显示出更强的药效作用。
[Key word]
[Abstract]
Objective To explore the possibility for application of ultrafiltration membrane technology to purify Rhizoma Corydalis Decumbentis total alkaloids (RCDTA). Methods Based on the index related to protopine, to investigate the effect of different aperture membrane and orthogonal test of separation parameters on membrane saparation efficiency of Xiatianwu Injection. Results The PS membrane with 6×103-1.0×104 interception molecular weight had better separation efficiency and the preferred operation parameters were 0.08 MPa of pressure, 40 ℃ of liquid temperature, and 2.8 L/min of liquid speed. Conclusion Xiatianwu Injection prepared by ultrafiltration membrane technology is clear with good colour and better drug function.
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[基金项目]
江西省重大科技攻关项目(赣科发计字[2002]64号)