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[摘要]
目的研究担子菌黄卷缘齿菌Hydnum repandum的化学成分.方法通过硅胶、Sephadex LH-20、反相硅胶柱色谱分离化合物,运用氢谱、碳谱、 二维核磁共振(1H1-HCOSY,HM QC,HM BC,NOESY)、质谱、高分辨质谱、旋光鉴定结果.结果共分离鉴定了11个化合物,分别是:sarcodonin A(Ⅰ)、 scabronine B(Ⅱ)、3β-羟基-5α,8α-过氧麦角甾-6,22-二烯-3β-醇(Ⅲ)、(22E,24R)-麦角甾-7,22-二烯-3β,5α,6β-三醇(Ⅳ)、(22E, 24R)-麦角甾-7,22-二烯-3β-醇(Ⅴ)、苯甲酸(Ⅵ)、对羟基苯甲醛(Ⅶ)、对羟基苯甲酸乙酯(Ⅷ)、乙基-β-D-吡喃葡萄糖苷(Ⅸ)、硫代乙酸酐(Ⅹ)、(2S,2′R,3S, 4R)-2-(2-羟基-十八碳酰胺)二十二碳烷-1,3,4-三醇(Ⅺ).结论所有化合物都是首次在黄卷缘齿菌中分到.
[Key word]
[Abstract]
Objective To study the chemical constituents of the fruiting bodies of Hydnum repandum.Methods Separation and purificat-ion were performed on silica gel,Sephadex LH-20 and ODS CC.Their sturctures were established by 2D-NMR(1H-1 HCOSY, HMQC,HMBC,and NOESY), MS,HR-MS spectra,and ORD data.Results Eleven compounds were obtained and identified as sarcodonin A(I),scabronine B(Ⅱ),3β-hydroxy-5α,8α-epidioxyergosta-6,22-dien(Ⅲ),(22E,24R)-ergosta-7,22-diene-3β,5α,6ptriol(Ⅳ),(22E,24R)-ergosta-7,22-diene-3β-ol(V),benzoic acid(Ⅵ),4-hydroxylben-zaldehyde(V1),4-monopropanoylbenzenediol(Ⅷ),ethyl-β-D-glucopyranoside (Ⅸ),thioacetic anhydride(X),(2S,2 7R,3S,4R)-2-(2-hydroxyoctadecanoylamino)docosane-1,3,4-triol(XI). Conclusion A1l of the compounds are isolated from this fungus for the first time.
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[基金项目]
国家自然科学基金资助项目(30225048)