[关键词]
[摘要]
目的研究黄亮橐吾根和根茎的化学成分.方法利用硅胶、Sephadex LH-20柱色谱分离等方法进行分离和纯化,根据化合物的理化常数和波谱数据鉴定其结构.结果从黄亮橐吾的根和根茎中分离到8个化合物,分别鉴定为:泽兰素(euparin,Ⅰ)、6-甲氧基泽兰素(6-methoxy-euparin,Ⅱ)、2-羟基-4,5-二甲氧基苯甲醛(4,5-dimethoxy-2-hydroxybenzaldehyde,Ⅲ)、2-乙酰-5,6-二甲氧基苯并呋喃(2-acetyl-5,6-dimethyoxybenzofuran,Ⅳ)、对羟基苯乙酮(4-hydroxyacetophenone,Ⅴ)、2-isopropenyl-5,6-dimethoxy-2,3-hydrocumaran(Ⅵ)、8β-hydroxy-7(11)-eremophilen-12,8α-olide(Ⅶ)、羽扇豆醇(lupeol,Ⅶ).结论8个化合物均为首次从黄亮橐吾中分离得到.主要成分为苯并呋喃类化合物,特别是化合物Ⅰ和Ⅱ是两个重要的成分,具有杀虫和昆虫拒食活性,这和黄亮橐吾民间用于驱虫有相关性.
[Key word]
[Abstract]
Objective To study the benzofuran compounds from roots and rhizomes of Ligularia caloxantha.which iS a folk medicine used in the Naxi Nationality in Yunnan Province.Methods Compounds were separated and purified by silica gel and Sephadex LH一20 column chromatography.Their structures were elucidated by physicochemical properties and spectral analysis.Results Eighit compounds are isolated from ethanolic extracts of the roots and rhizomes.They were identified as euparin(I),6一methoxy—euparin(Ⅱ),4,5-dimethoxy-2一hydroxybenzaldehyde(Ⅲ),2-acetyl一5,6-dimethyoxy—benzofuran(Ⅳ),4-hydroxyacetophenone(V),2-isopropenyl一5,6-dimethoxy一2,3-hydrocumaran(VI),8p—hydroxy一7(11)-eremophilen一12,8a—olide(15),lupeol(Ⅷ).Conclusion All the eight compounds were,obtained from L.caloxantha for the first time as benzofurans.Compounds I andⅡare two major ones with inseeticide and insect food refusal—induced activities.That iS the relative reason of L.caloxantha used for folk anti—insect.
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[基金项目]
国家杰出青年基金资助项目(39825129)