[关键词]
[摘要]
目的研究山蒟Piperhancei藤茎的化学成分,为阐明其有效成分提供依据。方法利用硅胶、聚酰胺柱色谱进行化合物的分离,根据光谱数据(IR,UV,MS,1H-NMR,13C-NMR)和化学方法鉴定其结构。结果从其氯仿萃取物中分离得到9个化合物,分别鉴定为:凤藤酰胺(futoamide,)、毛穗胡椒碱(trichostachine,)、假荜拨酰胺A(retrofractamideA,)、胡椒次碱(pipercide,)、几内亚胡椒碱(guineensine,)、胡椒碱(piperine,)、胡椒亭(piperettine,)、卵形椒碱(piperovatine,)及(2E,4E)-N-异丁基-7-(3,4-次甲二氧基苯基)-2,4-二烯庚酰胺[(2E,4E)-N-isobutyl-7-(3,4-methylenedioxyphenyl)-hepta-2,4-dienamide,]。结论化合物~和~均为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents in the vines of Piper hancei for obtaining a more comprehensive understanding on its effective components.Methods Compounds were separated by column chromatography with silica gel and polyamide, and their structures were elucidated by spectral analysis and chemical evidence (IR, UV, MS, (~1H-NMR), (~(13)C-NMR)). Results Nine compounds were isolated from the chloroform extract fraction. Their structures were identified as: futoamide (Ⅰ), trichostachine (Ⅱ), retrofractamide A (Ⅲ), pipercide (Ⅳ), guineensine (Ⅴ), piperine (Ⅵ), piperettine (Ⅶ), piperovatine (Ⅷ), and (2E, 4E)-N-isobutyl-7-(3, 4-methylenedioxyphenyl)-hepta-2, 4-dienamide (Ⅸ). (Conclusion )Compounds Ⅱ-Ⅳ and Ⅶ-Ⅸ are isolated from the plant for the first time.
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[基金项目]
国家重点科技项目(攻关)计划(99-929-01-29)