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[摘要]
目的研究婆婆针Bidensbipinnata的化学成分,从中寻找具有抗癌和抗炎生物活性及药用前景的天然化合物。方法采用硅胶、聚酰胺和高效制备液相分离化合物,运用波谱技术分析确定化学结构。结果从婆婆针中得到10个化合物,鉴定了其中6个,分别为:鬼针聚炔苷()、2-β-D-吡喃葡萄糖基-1,13-二羟基-11(反)-十三烯-3,5,7,9-四炔()命名为鬼针聚炔苷B、金丝桃苷()、7,3′,4′-三羟基-6-(3″,6″-二乙酰氧基-β-D-吡喃葡萄糖基)-橙酮()、7,3′,4′-三羟基-6-(6″-乙酰氧基-β-D-吡喃葡萄糖基)-橙酮()、7,3′,4′-三羟基-6-(4″,6″-二乙酰氧基-β-D-吡喃葡萄糖基)-橙酮()。结论化合物为新化合物,化合物为首次从该植物分离得到。
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[Abstract]
Objective To study the chemical constituents of Bidens bipinnata and search for bioactive natural products, which have the anticancer and antiinflammation activities. Methods The six compounds were isolated by a combination of silica gel, reversed phase silica gel column chromatography, and polyamide column chromatography. Their structures were identified by spectral methods. Results Ten compounds were isolated and six structures were identified. They are trideca-2-β-D-glucopyranosyl-1, 13-dihydroxy-3 (E), 11 (E)-en-5, 7, 9-triyne (Ⅰ), trideca -2-β-D-glucopyranosyl-1, 13-dihydroxy-11 (E)-dien-3, 5, 7, 9-tetrayne (Ⅱ), hyperoside (Ⅲ), 6-O-(3″, 6″-diacetyl-β-D-glucopyranosyl)-6, 7, 3′, 4′-(tetrahydroxyaurone) (Ⅳ), 6-O-(6″-acetyl-β-D-glucopyranosyl)-6, 7, 3′, 4′-tetrahydroxyaurone (Ⅴ), 6-O-(4″, 6″-diacetyl-β-D-glucopyranosyl)-6, 7, 3′, 4′-tetrahydroxyaurone (Ⅵ). Conclusion Compound Ⅱ is a novel compound, compound Ⅴ is isolated from this plant for the first time.
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