[关键词]
[摘要]
目的 观察青龙衣不同提取部位的抗肿瘤作用.方法 制备S180和H22荷瘤小鼠模型,青龙衣不同提取部位ip给药,观察其对S180小鼠的抑瘤作用及对胸腺、脾脏器官指数的影响,对S180和H22荷瘤小鼠癌细胞膜和红细胞膜表面唾液酸(SA)含量的影响.结果 青龙衣冷、热醇提取部位对S180荷瘤小鼠均有明显的抑瘤作用,并呈良好的剂量-效应关系;对H22荷瘤小鼠可延长生存期;冷、热醇提取部位能显著降低S180和H22小鼠肿瘤细胞膜表面SA含量,同时显著提高荷瘤小鼠红细胞膜表面SA含量.结论 青龙衣冷、热醇提取部位具有抗肿瘤作用.
[Key word]
[Abstract]
Object To observe antitumor (DEQ).Methods S180-mice and H22-mice were effects of different extract fractions from Qinglongyi given by ip as model.Antitumor effects of DEQ on S180-mice were observed,and also the effect on indexes of thymus and spleen,sialic acid (SA) content in cancer cell cold membrane and erythrocyte membrane in S180-mice and H22-mice.Results The two extract fractions by and hot alcohol have obvious antitumor effects in a dose-effect manner to S18o-trice,and can prolong H22-mice life.The two extract fractions from Qinlongyi can significantly decrease SA in brane havend increase SA in erythrocyte membrane.Conclusion The two extract fractions cancer from Qinglongyi antitumor effects.
[中图分类号]
[基金项目]
黑龙江省自然科学基金项目(ZLY03-04)