[关键词]
[摘要]
目的 考察抗流感滴鼻剂的絮凝除杂工艺条件.方法 以澄清效果为指标,对影响Ⅲ型山东药圣1+1澄清剂絮凝除杂的5种因素进行了考察.以栀子苷量为定量考察指标,木兰脂素、栀子苷的TLC检识为表观考察指标,对Ⅲ型山东药圣1+1澄清剂絮凝、50%乙醇醇沉、75%乙醇醇沉除杂情况进行对比,确定最佳的除杂工艺条件.结果 采用优化后的絮凝除杂工艺条件,絮凝组中栀子苷含量明显高于50%、75%乙醇醇沉组;TLC显示,絮凝除杂组与原液组斑点基本一致.结论 Ⅲ型山东药圣1+1澄清剂在抗流感滴鼻剂的除杂工艺中,具有活性成分保留率高,操作简便,成本低廉,工艺稳定等优点,是较理想的除杂方法之一.
[Key word]
[Abstract]
Object To investigate the process of flocculation impurity removal for the Anti-flu Nose Drops (AND).Methods Five kind of effective factors on flocculation impurity removal with the index of clarifying Results were studied.Comparative tests for Shandong Yaosheng 1+1(Ⅲ)clarificant,5000 alcohol precipitation,and 75%alcohol precipitation were performed with the quantitative index of gardenoside contents,the qualitative index of magnolin and gardenoside TLC chromatograms.The optimum process condition was selected out.Results Under the optimum process condition of flocculation impurity removal,gardenoside contents in the flocculation group is higher than those in 50%,75%alcohol groups.TLC chromatograms showed that the spots of flocculation group are the same as those in the original liquid group.Conclusion Shandong Yaosheng 1+1(Ⅲ)clarificant has following advantages:high reserved rate of active components,simple operation,cheap cost,stable process,which is a ideal method for the impurity removal.
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[基金项目]
辽宁省科技厅资助项目(00226003)