目的 研究复方丹参片对实验性阿尔茨海默病 (AD)大鼠脑内氨基酸类神经递质含量的影响,揭示其防治AD的作用机制。方法 采用HPLC方法检测实验性AD大鼠脑内天冬氨酸 (Asp)、谷氨酸 (Glu)、甘氨酸(Gly)和γ 氨基丁酸 (GABA)等氨基酸类神经递质的含量。 结果 复方丹参片能明显降低实验性AD大鼠脑内兴奋性氨基酸Glu的含量,升高抑制性氨基酸Gly和GABA的含量。结论 复方丹参片降低兴奋性氨基酸含量,以对抗兴奋性氨基酸的毒性,这可能是其防治AD的机制之一。

Object To study the effect of Compound Danshen Ta blets (CDST) on the contents of amino acid neurotransmitters in brain of experimental Alzheimer's disease (AD) rats to reveal the mechanism of CDST in the prevention and treatment to AD.Methods Contents of amino acid neurotransmitters Asp, Glu, Gly, GABA in AD rat brain were determined by HPLC.Results CDST significantly decreased the excitatory Glu content, and increased the inhibitory Gly and GABA contents. Conclusion CDST could lower the toxicity of excitatory amino acid by decreasing its contents, which may be one of the mechanisms of CDST in prevention and treatment to AD.

广州市企业博士后基金资助项目 ( 2 0 0 2 0 2 )