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[摘要]
目的 观察 2 0 S-原人参二醇皂苷 (PPDS)对实验性高脂血症大鼠血清总胆固醇 (TC)、脂蛋白 -胆固醇代谢的影响及其抗氧化作用。方法 PPDS按 2 5,5 0,10 0 mg/ (kg· d)给大鼠连续 ip12 d,测血清 TC、脂蛋白 -胆固醇及脂质过氧化物 (L PO)含量,血浆前列腺素 I2 (PGI2 ),血栓素 A2 (TXA2 )水平,血清和肝脏超氧化物歧化酶(SOD)活性及全血黏度,并观察肝脏脂肪沉积情况。结果 PPDS 5 0,10 0 mg/ kg能明显降低甘油三酯 (TG),TC,低密度脂蛋白胆固醇 (L DL- c),TXA2,L PO含量及全血黏度,并能明显提高实验性高脂血症大鼠高密度脂蛋白胆固醇 (HDL-c),PGI2 含量及 SOD活性,亦能使 TC/ HDL-c及 L DL-c/ HDL-c比值明显降低,PGI2 / TXA2 比值明显升高。病理检查可见肝脏脂肪沉积明显减轻。结论 PPDS可能通过调节体内血脂代谢、提高 PGI2 / TXA2 比值及纠正自由基代谢紊乱发挥抗动脉硬化作用。
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[Abstract]
Object To observe the effect of 20S-protopanaxadiol saponins from Panax quinquefolium (PPDS) on total cholesterol, lipoprotein cholesterol metabolism and antioxidative activity in experimental hyperlipidemia rats. Methods The total cholesterol (TC), lipoprotein cholesterol, and lipid peroxidation (LPO) contents, prostaglandin I2(PGI2), thromboxane A2 (TXA2) levels, superoxide dismutase (SOD)activity and blood viscosity were measured in hyperlipidemia rats which have been given PPDS 25, 50, 100mg/(kg·d) byip, continuously for 12 days. In addition, fat accumulation in liver was observed. Results Triglyceride (TG), TC, low density lipoprotein cholesterol (LDL-c) in serum, TXA2 in plasma, LPO in serum and liver, and blood viscosity were decreased significantly; and high density lipoprotein cholesterol (HDL-c) in serum, PGI2 in plasma, and SOD in serum and liver were significantly increased by given HDL-c and LDL-c/HDL-c ratio, increase PGI2/TXA2 ratio, and inhibit fat accumulation in liver.Conclusion PPDS could inhibit arteriosclerosis by improving cholesterol and lipoprotein-cholesterol metabolism, suppressing LPO, and increasing the activity of SOD
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[基金项目]
吉林省科委科研基金资助项目(962901-1)