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[摘要]
目的研究影响舒胸滴丸制备的各种因素,确立最佳制备工艺。方法以滴丸圆整度和丸重为指标,采用正交设计试验法对影响因素进行考察。结果以聚乙二醇4000为基质,甲基硅油为冷却液,以内径为4.1mm、外径为6.1mm的滴管,20~30滴/min滴入120cm长的冷却柱中,采用梯度冷却(梯度冷却液的温度分布为40℃~50℃、10℃~30℃、0℃~4℃),所得滴丸的圆整度和丸重好,成品率高。结论该制备工艺成品率高,符合滴丸的质量要求,可用于舒胸滴丸制备。
[Key word]
[Abstract]
Object To optimize the best technical parameters through controlling the different factors. Methods Taking spherical degree and pill weight as index, the above factors were observed by orthogonal test. Results PEG4000 as matrix, methyl silicon oil as refrigerant. Internal and external diameter of burette are 4 1 mm and 6 1 mm, dropping into the refrigerant that composed of 40℃-50℃,10℃-30℃,0℃-4℃ by 20℃-30℃ droppings per minute. Conclusion The highest finished product with good quality can be got through this process.
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