目的 分离鉴定青叶胆Swertia mileensis 全草的酮类成分。方法 95%乙醇浸提,经硅胶柱色谱分离纯化, UV , IR, M S, 1H和13 CNM R波谱方法确定化学结构。,b>结果 分得12个酮成分,分别为1-羟基-2, 3, 4, 5-四甲氧基酮(1-hydro x y-2, 3, 4, 5-tetramethox yx antho ne, Ⅰ) ; 1-羟基-2, 3, 7-三甲氧基酮(1-h ydro xy-2, 3, 7-trimetho xy xa ntho ne,Ⅱ) ; 1-羟基-2, 3, 5, 7-四甲氧基酮(1-hy drox y-2, 3, 5, 7-tetr amethox y xa ntho ne,Ⅲ) ; 1, 5-二羟基-2, 3-二甲氧基酮(1, 5-dih ydro xy-2, 3-dimethox y xa ntho ne,Ⅳ) ; 1, 5-二羟基-2, 3, 7-三甲氧基酮(1, 5-dihydroxy-2, 3, 7-trimethox y xa ntho ne,Ⅴ) ; 1-羟基-2, 3, 5-三甲氧基酮(1-hy dr ox y-2, 3, 5-trimethox y xa ntho ne,Ⅵ) ; 1,5-二羟基-2, 3, 4, 7-四甲氧基酮(1, 5-dihydr ox y-2, 3, 4, 7-te trame tho x yx anthone, Ⅶ) ; 1, 8-二羟基-2, 3, 6-三甲氧基酮(1, 8-dihydro x y-2, 3, 6-trimethox yx a ntho ne , Ⅷ) ; 1-羟基-2, 3, 4, 7-四甲氧基酮(1-hydr ox y-2, 3, 4, 7-tetramethoxyx antho ne ,Ⅸ) ; 1, 2, 3, 5-四甲氧基酮(1, 2, 3, 5-te tromethox yx antho ne ,Ⅹ) ; 1-羟基-2, 3, 4, 6-四甲氧基酮(1-hy drox y l-2, 3, 4, 6-tetramethox yx antho ne, Ⅺ) ; 1-羟基-2, 3, 6, 8-四甲氧基酮(1-hydr ox yl-2, 3, 6, 8-tetramethoxyx antho ne ,ⅩⅡ)。结论 化合物Ⅰ ,Ⅲ ,Ⅳ ,Ⅴ ,Ⅶ ～ ⅩⅡ 为首次从青叶胆中分得。

Object Isolation and structural identification of xanthone derivative from medicinal plant Swertia mileensis T N Ho et W L Shih were carried out Methods The chemical constituents were isolated and purified by extensive silica gel column chromatography and their structures were elucidated by chemical evidences and spectral analysis Results There were 12 xanthone analogues named 1 hydroxy 2, 3, 4, 5 tetramethoxyxanthone, (Ⅰ); 1 hydroxy 2, 3, 7 trimethoxyxanthone, (Ⅱ); 1 hydroxy 2, 3, 5, 7 tetramethoxyxanthone, (Ⅲ); 1, 5 dihydroxy 2, 3 dimethoxyxanthone, (Ⅳ); 1, 5 dihydroxy 2, 3, 7 trimethoxyxanthone, (Ⅴ); 1 hydroxy 2, 3, 5 trimethoxyxanthone, (Ⅵ); 1, 5 dihydroxy 2, 3, 4, 7 tetramethoxyxanthone, (Ⅶ); 1, 8 dihydroxy 2, 3, 6 trimethoxyxanthone, (Ⅷ); 1 hydroxy 2, 3, 4, 7 tetramethoxyxanthone, (Ⅸ); 1, 2, 3, 5 tetromethoxyxanthone, (Ⅹ); 1 hydroxyl 2, 3, 4, 6 tetramethoxyxanthone, (Ⅺ); 1 hydroxyl 2, 3, 6, 8 tetramethoxyxanthone, (ⅩⅡ) Conclusion Compounds Ⅰ, Ⅲ, Ⅳ, Ⅴ, Ⅶ ⅩⅡ were first isolated from S. mileensis

国家自然科学基金重点项目 (No.2 973 2 0 40)