目的 研究泽泻不同溶剂提取物对大鼠尿草酸钙结石形成的影响 ,并确定其抑制尿草酸钙结石形成的有效部位。方法 通过 ig不同剂量的泽泻不同溶剂提取物对乙二醇和氯化铵诱导的大鼠肾草酸钙结石模型进行试验研究。结果 泽泻乙酸乙酯浸膏高剂量组大鼠的血清 Cr,BU N,肾 Ca2 +含量 ,2 4 h尿 Ca2 +分泌量 ,肾组织的草酸钙晶体沉积均明显低于成石组 (P<0 .0 5)。结论 泽泻乙酸乙酯浸膏能抑制实验性高草酸尿症大鼠尿草酸钙晶体的形成 ,是泽泻抑制尿草酸钙结石形成的有效部位。

Object To study the effect of different extracts of Alisma orientalis (Sam.) Juzep. on urinary calcium oxalate stone formation in rats and to identify the effective constituents. Methods Different extracts were administered through a stomach tube to rats of different groups with renal calcium oxalate stone induced by ethylene glycol (EG) and ammonium chloride (AC). Results In the rats administered with high dose of EtOAc extract, blood Cr, BUN, renal tissue calcium content, urinary calcium excretion and crystals deposition in renal tissue were significantly lower than that of the stone formation group. Conclusion The EtOAc extract of A. orientalis can inhibit urinary calcium oxalate stone formation in rats and seems to be the effective constituent of A. orentalis.

国家自然科学基金资助项目(39970891)