目的 研究六味地黄汤中马钱子素小鼠体内药代动力学。方法 高效液相色谱-紫外检测法。结果 六味地黄汤小鼠ig给药后,马钱子素的药代动力学模型为单室模型一级吸收 ,其药代动力学参数为 Ka=0.04min^-1 ,Ke=0.019min^-1,T(peak) =42.4min, t_1/2ke = 17.4min,t_1/2ke=35.75min。结论 此药代动力学参数可能是六味地黄汤中马钱子素受其他成分影响所致。

Object To study the pha rmaco kinetics of loganin in LIUWEI DIHU ANG DECOCTION(LWDHD) in mice. Methods HPLC-UV detection was used to determine the loganin levels in biological samples. Results Afterig LWDHD in mice, the plasma concentration-time course fitted well to one-compartment model with the 1st order absorption and with the following pha rmacokinetic parameters; Ka=0.04 min^{- 1} , Ke= 0.019 min^{- 1},T_(peak) = 42. 4 min, t_{1 /2ka}= 17.4 min, t_{1 /2ke}= 35.75 min. Conclusion The pharmaco kinetic parameters of loganin obtained in the study may be at tributed to the effect of other constituents in the DECOCTION.

国家重点基础研究发展规划项目(No.G1999054401)