目的 探讨超细粉体技术对中药制剂体外溶出度的影响 ,以及丸剂的粒径对溶出度的影响。方法 采用分光光度法,以盐酸小檗碱为指标成分,考察普通粉与超细粉二妙丸及不同粒径的超细粉二妙丸微丸的体外溶出度。结果 超细粉二妙丸的T50和Td分别为61.60,19.48,17.84,8.97min和102.3,33.2 9,26.98,14.77min;粒径为2.4mm的普通粉二妙丸的T50和Td 分别为89.61,155.68min。结论 超细粉二妙丸的溶出速率明显快于普通粉,且随着丸剂自身粒径的降低 ,体外溶出速率加快。

Object To investig ate the effects of ultra-fine powder technique and granularity of pellets on dissolution rate invitro. Methods The dissolution rate of ultra-fine ERM IAO PILL with different granule diameters invitrow as measured and compared with the index of berberine by UV spectro-photometry.Results The dissolution parameters T50 and Td of four kinds of ultra-fine ERM IAO PILL are 61.60,19.48, 17.84, 8.97 min and 102. 3,33. 29, 26.98, 14.77 min, respectively. Those of general powder ERMIAO PILL with granule diameter o f2.4 mm are 89.61 and 155. 68 min.Conclusion The dissolution rate of ultra-fine powder is quicker than that of general powder , and the rate increases with the granularity of PILL decreasing.

江苏省科委应用基础项目(BJ97137)