目的研究观光木树皮的化学成分和生物活性。方法运用生物活性跟踪的方法，对中国特有植物观光木(学名: 宿轴木兰)树皮乙醇浸膏的乙酸乙酯萃取部分和正丁醇萃取部分进行体外抗肿瘤活性筛选。结果这 2个萃取部分均具有抗肿瘤活性。用柱层析对活性部位进行化学成分研究，从乙酸乙酯部分分得 3个吉马烷型半萜内酯: 木香烯内酯 (Ⅰ)、小白菊内酯 (Ⅱ)和 11，13-二氢小白菊内酯 (Ⅲ)。从正丁醇部分得到 1个阿朴菲类生物碱: 鹅掌楸碱 (Ⅳ)、1个呋喃酮类化合物: 2，3-二羟基-2-甲基-丁内酯 (Ⅴ)。结论上述 5个化合物均为首次从该植物中分离得到。化合物Ⅰ 、Ⅱ 、Ⅳ、Ⅴ 分别对所测试的不同肿瘤细胞株具有较好的细胞毒活性。

Object To study the chemical constituent and the bioactivity in the bark of Tsoongiodendron odorum Chun. Methods By bioactive following method, the extracts of both EtOAc and n BuOH in the bark of T odorum were screened for in vitro anti tumor activity. Results Five constituents were obtained Among them, three from EtOAc fraction belonged to germacranolides They were costunolide (Ⅰ), parthenolide (Ⅱ) and dihydroparthenolide (Ⅲ) The other two were from the fraction of n BuOH, one was an oxoaporphinoid alkaloid, liriodenine (Ⅳ), and the last was a furanone, 2, 3 dihydroxyl 2 methyl butylrolactone (Ⅴ). Conclusion All the above five compounds are found for the first time from this plant Compounds Ⅰ, Ⅱ, Ⅳ, and Ⅴ show the cytotoxic activities against a variety of tumor cell strains, respectively

国家自然科学基金重点资助项目(29732040)