目的 考察川乌与防己配伍前后主要化学成分乌头碱、粉防己碱煎出量的变化,探讨两药配伍使用增效减毒作用的机制。方法 采用薄层扫描法分别测定合煎液和单煎液中乌头碱和 /或粉防己碱的含量。结果 川乌与防己配伍合煎,乌头碱、粉防己碱的煎出量均较单煎时降低。结论 川乌、防己配伍使用为其增效减毒作用提供了科学的依据

Object To determine the variety of aconitine and tetrandrin in decocting Radix Aconiti and Radix Stephaniae Tetrandrae separately and compatibly, and explore the mechanism of synergy between above two decocted herbs. Methods TLCS was used to determine the contents of aconitine and tetrandrin in separate decoctions and compatible decoction, respectively. Results The contents of both aconitine and tetrandrin were less in compatible decoction than in separate ones. Conclusion A scientific basis is provided by the compatible decoction of the two herbs for more effective and attenuate use.

国家自然科学基金资助项目(39670868)