目的 优选胃安冲剂的制备工艺.方法 以厚朴酚、白术多糖、盐酸小檗碱为指标成分,采用正交试验法对胃安冲剂的制备工艺进行优选.结果 优化工艺为:厚朴、枳实采用水提醇沉(20倍量水,0.5 h,提取3次,95%乙醇沉淀杂质);黄连采用95%乙醇回流提取,白术等其它药材采用水提法(24倍量水,提取2次,每次2 h,白术粒度为2～4 mm).结论 该工艺合理,有效成分提取效率高.

Object To optimize the preparation procedure for WEI'AN GRANULES Methods The optimum conditions of WEI'AN GRANULES were selected with the active components: magnolol, polysacchride of Rhizoma Atractylodis Macrocephalae and berberine hydrochloride as mark by orthogonal test Results The optimum preparative procedure was as follow: Cortex Magnoliae officinalis and Fructus Aurantii Immaturus were extracted with water and precipitated with alcohol (adding 20 fold water as much as medicine, extracting three times,0.5 h per time and precipitated with 95% alcohol to remove impurities); Rhizoma Coptidis was extracted with 95% alcohol by refluxing; Rhizoma Atracylodis Macrocephalae and other herbs were extracted with water (adding 24-fold water as much as medicine, extracting twice, 2 h per time, its granule size of Rhizorna Afracylodis Macrocephalae was 2 mm to 4 mm) Conclusion The optimum preparative procedure is reliable and the extracting ratio of active component is high.

广东省中医药管理局2000年立项科研课题(100070)