目的 探讨消瘀片组方的合理性。方法 采用动脉粥样硬化兔模型,观察消瘀片及其组分对体内 ET- 1和NO含量的影响。结果 消瘀片对降低血浆和血管壁组织中 ET- 1含量,增加血清和血管壁组织中 NO含量均较其相应组分的丹参水提物或山楂醇提物更明显。结论 丹参水提物和山楂醇提物合用后,对降低粥样硬化兔体内ET- 1和增加 NO含量具有明显的协同作用.

Object To determine the rationality of prescription of XIAOYU TABLETS. (Tablet for the elimination of blood stasis). Methods The effects of XIAOYU TABLETS and its individual constituents on endothelin 1 and nitric oxide in atherosclerotic rabbits were observed and compared. Results XIAOYU TABLETS showed stronger actions than its individual constituents (extract of Radix Salviae Miltiorrhizae or Fructus Crataegi) in decreasing the contents of endothelin 1 in plasma and atherosclerotic vessel wall and increasing the contents of nitric oxide in serum and atherosclerotic vessel wall. Conclusion The combine use of Radix Salviae Miltiorrhizae and Fructus Crataegi extracts showed an obvious synergistic effect on reduction of endothelin 1 and elevation of nitric oxide in atherosclerotic rabbits.

香港保健协会资助项目(No.960086)