[关键词]
[摘要]
目的 观察地黄苷 A对环磷酰胺致小鼠白细胞减少症的影响。方法 利用环磷酰胺 ip造成小鼠白细胞减少症模型,地黄苷 A进行治疗,对模型小鼠体重、外周血象、网织红细胞数、脾脏指数、骨髓有核细胞数和 DNA含量进行检测。结果 地黄苷 A可明显升高模型小鼠的白细胞数、红细胞数、血小板数、网织红细胞数、骨髓有核细胞数和 DNA含量及体重。结论 地黄苷 A具有明显升白作用.
[Key word]
[Abstract]
Object To observe the effects of rehmaionoside A on mice leukopenia models induced by cyclophosphamide. Methods Mice leukopenia models were prepared by ip cyclophosphamide and then treated with rehmaionoside A. The levels of body weight, peripheral hemogram, reticulocyte count, spleen index, bone marrow karyocyte count and contents of bone marrow DNA were determined. Results Rehmaionoside A could obviously raise the counts of white blood cell, red blood cell, platelet, reticulocyte and bone marrow karyocyte, contents of bone marrow DNA, and body weight of the leukopenia model. Conclusion Rehmaionoside A has apparent leukogenic and antianemic actions.
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[基金项目]
国家中医药管理局资助(No.95Y3411);国家“九·五”科技攻关项目(No.96-903-02-04)