目的 研究西洋参叶 2 0 S-原人参二醇组皂苷 (PQDS)对急性心肌梗死大鼠交感神经递质及肾素 -血管紧张素系统 (RAS)的影响。方法 通过大鼠结扎左冠状动脉前降支 (L AD)急性心肌梗死模型 ,测定心肌梗死面积 ,血清肌酸磷酸激酶 (CK)及乳酸脱氢酶 (L DH)活性 ,血清去甲肾上腺素 (NE)及肾上腺素 (E)含量 ,血清血管紧张素转化酶 (ACE)及血浆肾素 (R)活性。结果 PQDS12.5 ,2 5 ,5 0 m g/kg舌下静脉给药 ,对急性心肌梗死 2 4 h大鼠可明显缩小心肌梗死面积 ,降低血清 CK及 L DH活性 ,并明显降低血清 NE、E含量及血清 ACE和血浆 R活性。结论 PQDS对急性心肌缺血具有保护作用 ,可能与其抑制交感 -肾上腺髓质过度兴奋 ,减少儿茶酚胺 (CA)大量分泌及其抑制 RAS激活 ,减少血管紧张素 (Ang)生成 ,打破 CA与 RAS相互促进造成的恶性循环等机制有关。

ObjectTo study the effect of Panax quinquefolius L. 20S-protopanaxdiolsapo nins derived from leav es of P. quinquefolius (PQDS) on sympa thetictransmit terand renin-a ngio tesin system (RAS) in rats with acute myocardial infarction. Methods Rat acute myo cardial infarction models were prepared by lig ating left a nterior descending co ronary artery (LAD) . The changes of myocardial infarct size, serum creatine phosphokinase (CK) , lactic dehydrog enase (LDH) , serum no radrenaline (N E) , adrenaline (E) , contents, serumangiotensin converting enzyme (ACE) and plasma renin activi ties were determined. Results The my ocardial infarct size, serum CK and LDH activities, no radrenaline and adrenaline contents were sig nificantly reduced, after ivinjection through sublingual vein 12. 5, 25, and 50 mg/kg of PQDS, 24 haftermyo cardial infarction. The serum ACE and plasma renin activities were also decreased markedly. Conclusion PQDS showed protective effect on acut myocardial ischemia , possibly due to its action to inhibi t hyperesthesia of sympathetic-adrenal medulla, by decreasing catecho lamines (CA) level and angio tensin Ⅱ (Ang Ⅱ) production and interferes the vicio us cycle caused by synergic actio ns betw een CA and RAS.

吉林省科委新药基金