[关键词]
[摘要]
目的 研究补阳还五汤的抗血栓有效部位及其活性成分。方法 用多种色谱和光谱方法对补阳还五汤水煎液乙酸乙酯萃取部位的化学成分进行分离和结构鉴定。结果 分离鉴定了 4个异黄酮化合物和 1个紫檀烷类化合物 ,分别为芒柄花素 (Ⅰ)、毛蕊异黄酮 (Ⅱ)、芒柄花素-7-O-β-D-葡萄吡喃糖苷 (Ⅲ)、毛蕊异黄酮-7-O-β-D -葡萄吡喃糖苷 (Ⅳ)及 (6a R,11a R) 9,10 -二甲氧基紫檀烷-3-O-β-D-葡萄吡喃糖苷 (Ⅴ)。结论 以上化合物均为首次从补阳还五汤中分离得到。
[Key word]
[Abstract]
ObjectTo study the antithombotic portion and bioactive fraction of BUY ANG HU ANWUT ANG (BHT) , a decoction of astragalus in combination with peony and several other ing redients. Methods The EtO Acportion of BHT extract was repeatedly separated by chromatography and identified by means of spectral analysis. Results One pterocarpan, (6aR , 11aR) 9, 10-dimetho xy pteroca rpan-3-O-β- D-glucopy ano side (Ⅴ) and fourisoflavones, formononetin (Ⅰ) , calycosin (Ⅱ) , fo rmononetin-7-O-β-Dg lucopyanoside (Ⅲ) , and caly cosin-7-O-β -D-g lucopyranoside (Ⅳ) were identified. Conclusion All five compounds were isolated for the first time from BHT.
[中图分类号]
[基金项目]
国家“九·五”攀登项目 “补阳还五汤治疗缺血性脑中风作用机理研究”的部分工作